Which Schedule of drugs has accepted medical use but is considered at high risk for abuse and dependence?

The correct answer is Schedule II. This schedule includes drugs that have widely recognized medical uses but are also deemed to have a high potential for abuse and can lead to severe psychological or physical dependence. Common examples of Schedule II substances include opioids like oxycodone and stimulants like amphetamine, which are used in treating conditions such as severe pain and ADHD. Due to their high potential for dependence, these drugs are subject to strict regulations regarding prescription and dispensing.

In contrast, Schedule I drugs are considered to have no accepted medical use and a high potential for abuse, making them illegal in the United States. Schedules III and IV include substances with lower abuse potential compared to Schedule II, with Schedule III having moderate potential and Schedule IV having a lower risk overall. Therefore, the classification of Schedule II drugs accurately reflects the balance between their accepted medical use and the risks they pose for addiction.