Which of the following are specifiers used in Substance Dependence diagnosis?

The option referencing "early full remission and on agonist therapy" is aligned with the established diagnostic criteria for Substance Dependence. In the context of substance use disorders, specifiers are used to provide additional detail about the disorder's presentation.

"Early full remission" indicates a period where the individual has shown a significant reduction in substance use and has experienced no symptoms for at least three months, marking progress in recovery. The phrase "on agonist therapy" describes a treatment modality used in managing substance use disorders, particularly with opioids. This therapy helps stabilize individuals by reducing cravings and withdrawal symptoms, thereby facilitating recovery.

This option is correct as it directly represents diagnostic specifiers that highlight both the current status of the disorder (remission) and treatment engagement, which are essential for a comprehensive understanding of the individual's condition. The other options do not accurately reflect established specifiers in the context of Substance Dependence diagnosis and instead focus on various issues or challenges that may accompany substance use but do not directly pertain to the diagnostic criteria.