What is the likely pharmacological effect when alcohol and barbiturates are taken together?

The combined use of alcohol and barbiturates typically results in a synergistic pharmacological effect. This means that when these two substances are taken together, their effects are enhanced beyond what either substance would produce alone. Both alcohol and barbiturates are central nervous system depressants, leading to increased sedation, respiratory depression, and impairment in motor and cognitive functions. The risk of overdose and serious health consequences is significantly heightened due to this synergistic effect, making it critical for individuals to understand the dangers of mixing these substances.